Coagulation System: What is It and How Can I Support It?

The cardiovascular system is perhaps one of the most important and well-recognized structures in the body. Within this system is an underlying and supporting framework that allow for healthy living. The coagulation system is one element of this framework that is essential for proper cardiovascular function. An imbalance of the coagulation system can result in life-threatening issues.

Typically, coagulation imbalances promote arterial clotting thereby increasing risk of heart attack, stroke, and cardiovascular disease. Fortunately, it is possible to better regulate clot formation and coagulation through the use of a supplement such as HoltraCeuticals’ Fibrinex.

Coagulation and Fibrin

The coagulation system plays an important role in the formation and dissolution of clots by regulating specific proteins including fibrin. When the body suffers from chronic infection it attempts to separate the infected area by surrounding it with durable fibrin. This is beneficial in the immediate because it acts as a barrier and blocks the spread of harmful substances. However, fibrin buildup also impedes the transport of nutrients, medicines, hormones and oxygen. Additionally, waste products and toxins cannot escape from afflicted vessels. Therefore, excess fibrin can prolong illness and worsen symptoms.

Irregular coagulation resulting in greater fibrin and fibrinogen production is most frequently seen among individuals suffering from chronic fatigue syndrome and fibromyalgia. However, other factors such as trauma, cytokines, and infectious agents can also trigger unhealthy coagulation activation. You can help your body better regulate fibrin production and protect against unhealthy clotting, cardiovascular disease, and stroke by taking Fibrinex.

What is Fibrinex?

Fibrinex is a specialized supplement produced by HoltraCeuticals that helps normalize coagulation. It is most beneficial to those suffering from chronic fatigue syndrome and fibromyalgia. However, it is also useful in treating any condition that involves an excess buildup of fibrin around the cells.

Fibrinex is made with ingredients that promote healthy enzymatic activity. Fibrinex increases production of a precursor enzyme called plasminogen, which helps improve levels of plasmin. Plasmin is the only fibrin-dissolving enzyme naturally produced in the human body. Fibrinex also support hydrolyzation of fibrin, allowing for more efficient breakdown and expulsion of unnecessary clotting proteins. Elimination of these substances allows for easier delivery of resources to cells and removal of harmful substances from them.

What’s in Fibrinex?

The ingredients of Fibrinex are what make it an effective coagulant regulator. Three powerful enzymes in the form of nattokinase, lumbrokinase, and bromelain are present in Fibrinex. Each of these naturally occurring substances have exceptional clot regulating properties and provide many notable health benefits.


Nattokinase is an enzyme found in the traditional fermented Japanese food, Natto. Nattokinase is produced when that active ingredient of the fermentation process, a bacterium called Bacillus natto, attempts to consume the essential soybean component of Natto.

There are several benefits that nattokinase provides. Perhaps most notable is its fibrinolytic, or fibrin-dissolving, capability. Its efficacy at breaking down fibrinogen, the soluble form of fibrin, makes it a powerful compound for combating unhealthy blood clots and atherosclerotic plaque. Both of which increase the risk of cardiovascular disease. Furthermore, nattokinase may help reduce the risk of heart disease by reducing LDL or bad cholesterol and increasing HDL or good cholesterol.

Nattokinase also supports cardiovascular health by regulating blood pressure. A double-blind study composed of 73 patients with untreated moderate high blood pressure showed that Nattokinase may significantly improve blood vessel health. It was found that once the eight-week nattokinase treatment was concluded, those taking the supplement presented an impressive reduction in both systolic and diastolic blood pressure. Elevation in either of these factors may indicate a risk for heart disease.


Lumbrokinase is an enzyme sourced from a species of earthworm called Lumbricus rubellus. Like nattokinase, lumbrokinase is a fibrinolytic enzyme supports the breakdown of fibrin.

In addition to aiding in fibrin dissolution, lumbrokinase provides many other benefits including, improved blood flow, reduction in cramps and pain, and deeper delivery of medication, supplements, and nutrients into tissues. Some experts suggest that because of these powerful benefits, lumbrokinase may be able to help treat conditions such as angina, diabetes, heart disease, Lyme disease, and stroke.

Multiple studies have shown that lumbrokinase may have impressive cardioprotective attributes. A 2013 study composed of 310 individuals who were hospitalized for stroke caused by arterial blockage in the brain (ischemic stroke) found that therapies that included lumbrokinase were more effective than standard stroke treatments. At the end of the study, those who received treatment including lumbrokinase experienced fewer ischemic strokes. Using lumbrokinase in stroke treatments or taking a supplement as a preventative measure for those at risk for stroke may reduce their overall occurrence.


Bromelain is composed of proteases found in pineapples. This enzyme is a primary component of the dissolving qualities many have come to associate with the tasty fruit.

Bromelain supplements are widely used for a variety of reasons. Taking bromelain or a supplement containing bromelain can provide many benefits including: reduction of inflammation and swelling, better immune function, hastened healing of wounds, sinusitis relief, cancer prevention, better blood flow, and more.

Bromelain is perhaps best recognized for supporting digestion and protein breakdown. One of the most popular uses of bromelain is as a digestive aid. Due to its impact on protein, you can take bromelain after a meal to improve nutrient digestion and absorption. The protein-dissolving attribute of bromelain also makes it exceptionally effective at breaking down fibrin. Therefore, bromelain not only benefits digestion but also supports heart health and limits arterial clotting.

Keep the Body Moving by Taking Fibrinex

The body’s coagulation system is a critical component of wellness. Unfortunately, abnormal activation of this system can lead to arterial issues, blockages, and disrupted blood flow. Fortunately, the impressive regulatory action of Fibrinex can combat coagulation difficulties. The unique formulation of quality enzymes found in Fibrinex supports greater arterial function, improves dissolution of clots, limits unhealthy clot production, and provides many other enzymatic benefits. Support cardiovascular wellness and prevent unhealthy coagulation associated with chronic conditions by taking Fibrinex.


Those who have conditions that increase the risk of bleeding, pregnant women, nursing mothers, and children should not take Fibrinex. Speak with a doctor before taking a supplement that contains bromelain, such as Fibrinex, if you are taking any of the following medications: antibiotics, anticoagulants, antiplatelet drugs, or sedatives.


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