The occurrence of diabetes, high blood pressure, obesity, and other cardiometabolic issues appears to be increasing on a global scale. This is highly concerning as these conditions are major contributors to serious health issues including cardiovascular disease. Fortunately, it may be possible to limit the occurrence of these notable health issues.

Glucorol is a supplement produced by HoltraCeuticals that focuses on supporting metabolic processes and reducing factors of heart disease. Read on to learn about the many benefits that come with taking Glucorol and decide if this supplement is right for you.  

What is Glucorol and What Does It Do?

Glucorol is a doctor-formulated supplement that helps improve factors of cardiometabolic disease including blood glucose, insulin, triglycerides, and cholesterol. Research suggests that the ingredients in Glucorol regulate these factors better than some prescription medications. Furthermore, the ingredients found in Glucorol support cardiovascular wellness by lowering both systolic and diastolic blood pressure. Improving these factors of cardiometabolic activity can notably reduce the risk of developing many chronic life-threatening conditions.

What’s in Glucorol?

The two primary ingredients of Glucorol, berberine and grape seed extract (in the form of MegaNatural) are naturally occurring and considered exceptionally safe. These powerful substances have a positive impact on many processes but are especially noted for their ability to regulate cardiometabolic factors.

Benefits of Berberine

Berberine is an alkaloid found in many natural herbs. This exceptionally safe substance has antimicrobial and anti-inflammatory qualities as well as being a powerful regulator of insulin, blood pressure, and blood glucose. These attributes make berberine exceptionally effective at combating many factors of cardiometabolic dysfunction and disease. However, the most impressive benefits of berberine pertain to its impact on diabetes, cholesterol, obesity, and cardiovascular function.

Diabetes

Diabetes is a condition caused primarily by poor insulin and blood glucose regulation. Maintaining elevated blood sugar levels for an extended period increases the risk of diabetes, damage to tissues and organs, and promotes the occurrence of life-threatening conditions such as cardiovascular disease.

Berberine has proven to be effective for treating factors of diabetes. Multiple studies have found that diabetics treated with berberine saw a drop-in blood sugar levels comparable to that of popular diabetic drugs. Other studies show that supplementing with berberine also has a positive effect on insulin resistance, glucose and lipid metabolization, bacteria balance in the gut, and digestion of carbohydrates. Improving these areas not only helps treat diabetes itself but also reduces risk factors of cardiovascular disease.

High Cholesterol

Berberine may aid in reducing cholesterol. Traditionally, high cholesterol is treated with statins. Although this therapy generally has a positive effect on cholesterol levels, it is associated with an increased risk for diabetes and the occurrence of serious side effects – learn more about the side effects of statins here. Alternatively, according to a review of 11 medical studies, berberine is able to reduce total cholesterol, reduce LDL or “bad” cholesterol, reduce blood triglycerides, and increase HDL or “good” cholesterol while limiting the risk of diabetes and having minimal side effects.

Obesity

Obesity is a major contributor to cardiometabolic issues. Fortunately, berberine may be able to support better weight regulation. Berberine has the ability to activate an enzyme known as AMPK. AMPK is often called the “metabolic master switch” because it has significant influence over metabolic activity. Activation of AMPK supports fat burning and subsequent weight loss. Berberine also supports the activity of other fat-regulating substances such as insulin, adiponectin, and leptin. Better management of these substances may promote weight loss and improve cardiometabolic function.

Cardiovascular Benefits

In addition to regulating the above factors of cardiovascular disease, berberine may provide specific support to heart health. Berberine triggers the release of nitric oxide, which helps relax the arteries, improve blood flow, reduce blood pressure, and prevent atherosclerosis or hardening of the arteries. These benefits were confirmed in a study by the University of Maryland Medical Center showing that those who took berberine for an eight-week period presented improved heart function and greater ability to exercise.

Benefits of Grapeseed Extract (MegaNatural)

Research into grapeseed extract confirms that this natural substance has significant regulatory benefits regarding blood pressure and cholesterol. Grape seed extract contains a large number of flavonoids called oligomeric proanthocyanins (OPCs). OPCs have powerful antioxidant properties, reduce blood pressure, and help regulate cholesterol. These attributes make grapeseed extract particularly beneficial for those with hypertension, high cholesterol, and an irregular glycemic response.

High Blood Pressure

Multiple studies show that grapeseed extract may be used to significantly reduce blood pressure. Research done at the University of California Davis showed that individuals with metabolic syndrome and those with hypertension saw decreases in both systolic and diastolic blood pressure after undergoing therapies with grapeseed extract. Another study using MegaNatural, a patented form of grapeseed extract, showed that daily oral dosing caused a notable reduction in blood pressure. Therefore, those interested in lowering their blood pressure may find that supplements containing grape seed extract, such as Glucorol, are useful for reaching their goals.

High Cholesterol

Studies show that taking grape seed extract reduces the number of oxidized LDL particles while also lowering overall LDL cholesterol levels. One study composed of 52 participants with moderately high cholesterol were treated with either grapeseed extract or a placebo over a period of eight weeks. Those given the grapeseed extract saw a significant decline in overall cholesterol, LDL cholesterol, and oxidized LDL. These benefits were more pronounced in those with cholesterol irregularities. The results of this study suggest that taking grape seed extract notably reduces the risk of atherosclerosis and cardiovascular disease.

Taking Action Against Cardiometabolic Disease

With rates of cardiovascular disease and metabolic disorders rising, it is becoming increasingly important to take proactive action. Glucorol’s powerful formulation offers antimicrobial and anti-inflammatory benefits. Regularly taking Glucorol may also improve regulation of cardiometabolic factors such as insulin, blood pressure, cholesterol, and blood glucose.

Those at risk for diabetes, cardiovascular disease, stroke, and heart attack may benefit greatly from taking Glucorol. However, even if a person is not currently diagnosed with or at risk for cardiometabolic disease, their proactive use of Glucorol may help alleviate cardiometabolic problems and protect against potential cardiovascular events.

Resources

1. NIH Staff. “Berberine.” NIH.
2. Chi-Li Kuo et al. “The anti-inflammatory potential of berberine in vitro and in vivo.” https://doi.org/10.1016/j.canlet.2003.09.002
3. Hao Zhang et al. “Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression.” https://doi.org/10.1016/j.metabol.2009.07.029
4. Yang, Jing et al. “Berberine improves insulin sensitivity by inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic syndrome patients.” Evidence-based complementary and alternative medicine : eCAM vol. 2012 (2012): 363845.
5. Ming Zhang et al. “Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis.https://doi.org/10.1016/j.mce.2012.08.006
6. Wu, Ueyue et al. “Protective effects of berberine on high fat-induced kidney damage by increasing serum adiponectin and promoting insulin sensitivity.” International journal of clinical and experimental pathology vol. 8,11 14486-92. 1 Nov. 2015.
7. Yin, Jun et al. “Efficacy of berberine in patients with type 2 diabetes mellitus.” Metabolism: clinical and experimental vol. 57,5 (2008): 712-7.
8. Li, Xiao-Yang et al. “Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters.” Journal of translational medicine vol. 13 278. 27 Aug. 2015.
9. Gregory Curfman, MD. “PCSK9 inhibitors: a major advance in cholesterol-lowering drug therapy.” Harvard Health Publishing.
10. Yueshan Hu et al. “Lipid-lowering effect of berberine in human subjects and rats.” https://doi.org/10.1016/j.phymed.2012.05.009
11. Chi‐Wai Lau et al. “Cardiovascular Actions of Berberine.” https://doi.org/10.1111/j.1527-3466.2001.tb00068.x
12. Kris Gunnars, BSc. “Berberine – A Powerful Supplement With Many Benefits.” Healthline.
13. Kathleen Jade, ND. “Grape Seed Extract Benefits Blood Pressure and Cholesterol.” University Health News.

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