The world is full of environmental toxins and agents of illness that can build up over time and overwhelm our defenses. The body’s ability to detoxify is essential in preventing toxic overload and subsequent disease. By supporting the body’s natural detoxification processes, you can reduce the impact of toxins and other harmful substances. You can accomplish this by using a quality supplemental product like HoltraCeuticals’ Phase II, which supports greater detoxification, antioxidant activity, and promotes general wellness.
How Detoxification Works
The liver is the body’s primary hub of detoxification. This essential organ eliminates toxins through the use of two pathways known respectively as phase 1 and phase 2 detoxification. Phase 1 uses various enzymes to break down chemicals and substances with the greatest toxicity into more manageable components. During this process, potentially damaging molecules called free radicals are produced. Unfortunately, increased presence of free radicals raises the risk for serious illness, including liver damage and even cancer.
Phase 2 detoxification, or the conjugation pathway, neutralizes the harmful molecules and toxins that remain after phase 1. Enzymes used in phase 2 convert the lingering substances (drugs, hormones, free radicals, etc.) into water-soluble compounds so they can be easily excreted through bile or urine. If not properly supported, phase 2 may not effectively remove the erroneous substances. Such a situation can lead to the occurrence of infection, chronic illness, or other serious disease. Fortunately, the detoxification process may be supported through the use of HoltraCeuticals’ Phase II.
What is Phase II?
Phase II is a once daily supplement that supports various factors of detoxification while also improving other elements of wellness. The high-quality ingredients in Phase II encourage improved regulation of phase 2 detoxification, allowing for greater elimination of toxins and harmful molecules that may be acquired from the environment or produced during phase 1.
What’s in the Phase II Detox Supplement?
The primary ingredient in Phase II is a powerful and long-lasting antioxidant called glucoraphanin. This exceptional phytonutrient is naturally found in broccoli and is associated with several impressive health benefits, including greater detoxification. Studies suggest that this powerful compound is one of the chief reasons hearty cruciferous vegetables like broccoli are so good for us. Just one capsule of Phase II is equivalent to one and a half pounds of broccoli, meaning that Phase II contains a large amount of beneficial nutrients such as glucoraphanin and by extension sulforaphane.
What Does Phase II Do?
Glucoraphanin is a precursor to an important detoxifying enzyme called sulforaphane that supports natural detoxification. Sulforaphane does so by inhibiting the activity of enzymes in phase 1 detoxification associated with the production of pro-carcinogens that may be later metabolized into cancer-promoting substances. Additionally, sulforaphane upregulates activity of enzymes used in phase 2 detoxification encouraging the removal of carcinogens and other xenobiotic or disease-causing substances.
The field of epigenetics is the study of a component of DNA that controls the activity level, function, and production of certain cells. Recent research suggests that sulforaphane may positively influence the outer layer of DNA in a way that encourages disease-fighting functions and other health benefits. Because it encourages increased values of sulforaphane, supplementation with Phase II may provide notable improvement of the following areas:
Sulforaphane may influence epigenetic factor of cancer cells, turning off malignant cells or coding that causes certain cancers to develop or worsen. Specifically, sulforaphane may help prevent and treat throat, lung, colon, prostate, breast, bladder, and skin cancers.
Sulforaphane may help the lungs eliminate environmental toxins associated with allergies, asthma, and other forms of respiratory illness. It may also ease oxidative stress connected to asthma and respiratory viruses.
Sulforaphane may reduce brain swelling when administered directly after traumatic brain injury, reducing the risk of cognitive loss. It may also limit the risk of stroke, cerebral palsy, and other neurological disorders when taken in supplemental form.
Sulforaphane may combat osteoporosis by inhibiting inflammation connected to osteoblast formation.
Concerns of Quality
The many benefits of sulforaphane may be acquired through use of supplements like Phase II that contain glucoraphanin. However, it is important to consider the quality of the supplements.
In their natural state, brassica vegetables such as broccoli sprouts, kale, arugula and others, contain myrosinase, an enzyme that is used to break down glucoraphanin into beneficial components such as sulforaphane. If there is not adequate myrosinase, the bioavailability of sulforaphane is reduced significantly. Unfortunately, many glucoraphanin or sulforaphane supplements use broccoli extract from sources that have diminished myrosinase content. This can inhibit the conversion of glucoraphanin into sulforaphane and its bioavailability.
Phase II contains glucoraphanin sourced from broccoli seeds, which are considered to have much higher concentrations of myrosinase. This facilitates greater bioavailability of the powerful detox-boosting phytonutrients in Phase II.
Support Long-Lasting Wellness with Phase II
We are exposed to toxins, disease-carrying substances, and harmful bacteria on a daily if not hourly basis. As these toxins build up in our system, the body must eliminate them through natural detoxification methods. If the system cannot keep up with the toxic load or is malfunctioning, our risk of developing serious illness or perpetuating existing conditions increases significantly. It is essential that the body’s natural detoxification systems work as intended. You can help ensure that your body detoxifies at its best by using HoltraCeuticals’ Phase II. Supplying your body with powerful high-quality phytonutrients like glucoraphanin and by extension sulforaphane supports healthy detoxification while also improving other important areas of wellness.
Resources1. CHI. “Phases of Detox.” Cincinnati Health Institute.
2. Bazzano, Lydia A et al. “Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study.” The American journal of clinical nutrition vol. 76,1 (2002): 93-9.
3. Zhang, Xianglan et al. “Cruciferous vegetable consumption is associated with a reduced risk of total and cardiovascular disease mortality.” The American journal of clinical nutrition vol. 94,1 (2011): 240-6.
4. Lee, Young-Sang et al. “Chemopreventive glucosinolate accumulation in various broccoli and collard tissues: Microfluidic-based targeted transcriptomics for by-product valorization.” PloS one vol. 12,9 e0185112. 25 Sep. 2017.
5. Royston, Kendra J, and Trygve O Tollefsbol. “The Epigenetic Impact of Cruciferous Vegetables on Cancer Prevention.” Current pharmacology reports vol. 1,1 (2015): 46-51.
6. Martin, Samantha L et al. “Mechanisms for the Inhibition of Colon Cancer Cells by Sulforaphane through Epigenetic Modulation of MicroRNA-21 and Human Telomerase Reverse Transcriptase (hTERT) Down-regulation.” Current cancer drug targets vol. 18,1 (2018): 97-106.
7. Abbaoui, Besma et al. “Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention.” Molecular nutrition & food research vol. 62,18 (2018): e1800079.
8. Li, Yanyan, and Tao Zhang. “Targeting cancer stem cells with sulforaphane, a dietary component from broccoli and broccoli sprouts.” Future oncology (London, England) vol. 9,8 (2013): 1097-103.
9. ASC. “Effects of Diet and Physical Activity on Risks for Certain Cancers.” American Cancer Society.
10. Vasanthi, Hannah R et al. “Potential health benefits of broccoli- a chemico-biological overview.” Mini reviews in medicinal chemistry vol. 9,6 (2009): 749-59.
11. University of California – Los Angeles. “Broccoli May Help Protect Against Respiratory Conditions Like Asthma.” ScienceDaily. ScienceDaily, 4 March 2009.
12. Sun, Beibei et al. “Effects of sulforaphane and vitamin E on cognitive disorder and oxidative damage in lead-exposed mice hippocampus at lactation.” Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) vol. 44 (2017): 88-92.
13. Yu, Chang et al. “Sulforaphane improves outcomes and slows cerebral ischemic/reperfusion injury via inhibition of NLRP3 inflammasome activation in rats.” International immunopharmacology vol. 45 (2017): 74-78.
14. Roman Thaler, et al. “Anabolic and anti-resorptive modulation of bone homeostasis by the epigenetic modulator sulforaphane, a naturally occurring isothiocyanate.” Journal of Biological Chemistry. January 12, 2016.