Many people experience a seemingly unending struggle with fatigue, foggy thinking, and malaise. Most attribute these issues to factors such as their heavy workload, stress, or aging. Although these elements may be a component, it is possible that there is a more definitive underlying issue; mitochondrial malfunction. If you can’t seem to keep your energy up and are experiencing symptoms associated with aging, you may benefit from boosting your mitochondrial function with a supplement like HoltraCeuticals’ Pyrro-Cell.
What is Pyrro-Cell?
Pyrro-Cell is a daily supplement produced by HoltraCeuticals’ designed to support and revitalize mitochondria. Mitochondria are the primary energy source of virtually every cell in the body. These small but powerful organelles generate energy in the form of adenosine triphosphate or ATP. ATP is the most widely used form of energy in the body. It is also the substance that cells use to activate biochemical processes that facilitate healthy bodily function.
Mitochondrial malfunction can cause a decline in cellular energy and activity resulting in symptoms such as fatigue, foggy thinking, muscle pain or weakness, respiratory issues, and more. Recent research also shows that poor mitochondrial health may also contribute to the development of degenerative disorders and speed up the aging process. Fortunately, it may ease mitochondrial dysfunction and restore your body’s vitality by supplementing with Pyrro-Cell.
What Does Pyrro-Cell Do?
Pyro-Cell improves various factors of mitochondrial production and activity. Supporting mitochondria in this way enables greater cellular energy, which can cascade into an array of health benefits. Those who supplement with Pyrro-Cell may find that they have a higher, more consistent energy level throughout the day, think more clearly, and experience fewer symptoms of aging. These benefits are all because of the high-quality ingredients found in Pyrro-Cell.
The Powerful Ingredients in Pyrro-Cell
Pyro-Cell is composed of three powerful ingredients, alpha lipoic acid, CoQ-10, and MicroPQQ. Each of these substances support mitochondrial function in various ways. We discuss the specific benefits of each ingredient below.
Alpha Lipoic Acid
Lipoic acid is an enzymatic cofactor that plays an essential role in mitochondrial activity. Perhaps most notably, lipoic acid facilitates biochemical reactions within mitochondria that allow them to convert sugars, proteins, and fats into useable energy in the form of ATP.
Supplementing with this naturally occurring compound has been shown to notably improve mitochondrial function, which provides many other health benefits.
Lipoic acid also has powerful antioxidant properties. This allows it to effectively eliminate agents of oxidative stress that can cause cellular damage and contribute to symptoms of aging. Lipoic acid limits inflammatory signals and stimulates the activation of an enzyme called heme oxygenase that encourages the destruction of oxidizing molecules. Studies show that because of these attributes supplementation with lipoic acid can markedly improve metabolic function and decrease oxidative stress. This has a significant influence on the occurrence of several chronic illnesses and serious health issues.
Research shows that supplementation with lipoic acid, or products that contain it such as Pyrro-Cell, may help prevent and sometimes reverse the effects of diabetes, obesity, insulin resistance, cardiovascular disease, and neurodegenerative disorders such as Alzheimer’s.
CoQ-10 is a precursor enzyme stored in the mitochondria. Much like lipoic acid, CoQ-10 plays an important role in the production of ATP while providing many other health benefits.
Studies show that supplementation with CoQ-10 helps protect mitochondria from oxidative stress, free radicals, and other oxidative agents. This can significantly improve energy production and prevent age-related illnesses. It has been found that CoQ-10 helps reduce the risk of neurodegenerative disorders. Research suggests that it does this by limiting the production of various substances that damage mitochondria and disrupt neurological function.
As we get older, the production of CoQ-10 decreases which can cause a decrease in cellular energy. Such a decline can speed up the aging process and encourage the development of age-related illnesses. Some of the most prominent issues associated with poor CoQ-10 values are heart disease, fibromyalgia, diabetes, muscle degradation, and neurodegenerative disorders. Fortunately, you may be able to alleviate these issues while supporting mitochondrial function by using a supplement like Pyrro-Cell that contains CoQ-10.
Pyrroloquinoline quinone, or more simply PQQ, is a bacterial substance found in nature that recent research suggests may provide incredible benefits regarding mitochondrial proliferation and function.
There are several ways in which MicroPQQ positively influences mitochondria. One of them being through regulating cell signaling. PQQ activates multiple cell signaling pathways; PGC-1, CREB, and DJ-1. The PGC-1 pathway stimulates genes that encourage mitochondrial proliferation, the CREB pathway promotes histones which protect and repair cell DNA and encourages mitochondria growth, and the DJ-1 pathway supports cellular function and longevity. Each of these factors can notably improve mitochondrial wellness, limiting the effects of aging and combating various age-related illnesses.
Studies show that PPQ also stimulates genes that trigger mitochondrial generation in older cells. This is exciting news as research suggests that increased proliferation of new mitochondria is closely tied to longevity and long-term wellness. PPQ further supports longevity due to its exceptional antioxidative attributes. The protective quality of PPQ increases mitochondria count and function by preventing oxidative damage and destruction. This suggest that supplementing with PPQ may improve individual longevity and wellness.
MicroPQQ, such as that found in Pyrro-Cell, is a micronized variant of naturally occurring PQQ. When compared to PQQ, MicroPQQ remains active for a longer period and has more than twice the bioavailability. These qualities mean that a small dose of MicroPQQ provides much greater benefit than standard PQQ supplements. You can attain all the benefits of Micro PQQ by supplementing with Pyrro-Cell.
Restore Wellness and Protect Your Future Health with Pyrro-Cell
Many argue that symptoms of aging such as fatigue, declining cognitive function, and physical degradation are unavoidable. In actuality, this may not be true. Studies suggest that supporting mitochondrial function may delay or even prevent many of the most common signs of aging. You can empower your mitochondria by supplementing with HoltraCeuticals’ Pyrro-Cell. The three exceptional ingredients found in Pyrro-Cell, alpha-lipoic acid, CoQ-10, and MicroPPQ, provide impressive mitochondrial support and protection. If you are looking to revitalize your body and combat the effects of aging, consider taking Pyrro-Cell.
Resources1. OSU. “Lipoic Acid.” Oregon State University.
2. Ibrahimpasic, Kanita. “Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment.” Medical archives (Sarajevo, Bosnia and Herzegovina) vol. 67,1 (2013): 7-9.
3. Farr, Susan A et al. “Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice.” Journal of Alzheimer’s disease : JAD vol. 32,2 (2012): 447-55.
4. Jariwalla, Raxit J et al. “Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection.” Journal of alternative and complementary medicine (New York, N.Y.) vol. 14,2 (2008): 139-46.
5. Quinzii, Catarina M et al. “Reactive oxygen species, oxidative stress, and cell death correlate with level of CoQ10 deficiency.” FASEB journal : official publication of the Federation of American Societies for Experimental Biology vol. 24,10 (2010): 3733-43.
6. Khakh, Baljit S, and Geoffrey Burnstock. “The double life of ATP.” Scientific American vol. 301,6 (2009): 84-90, 92.
7. McCarthy, S et al. “Paraquat induces oxidative stress and neuronal cell death; neuroprotection by water-soluble Coenzyme Q10.” Toxicology and applied pharmacology vol. 201,1 (2004): 21-31.
8. Isobe, Chiaki et al. “Levels of reduced and oxidized coenzyme Q-10 and 8-hydroxy-2′-deoxyguanosine in the cerebrospinal fluid of patients with living Parkinson’s disease demonstrate that mitochondrial oxidative damage and/or oxidative DNA damage contributes to the neurodegenerative process.” Neuroscience letters vol. 469,1 (2010): 159-63.
9. Shults, Clifford W et al. “Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline.” Archives of neurology vol. 59,10 (2002): 1541-50.
10. Harris, Calliandra B et al. “Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects.” The Journal of nutritional biochemistry vol. 24,12 (2013): 2076-84.
11. Itoh, Yuji et al. “Effect of the Antioxidant Supplement Pyrroloquinoline Quinone Disodium Salt (BioPQQ™) on Cognitive Functions.” Advances in experimental medicine and biology vol. 876 (2016): 319-325.
12. Ohwada, Kei et al. “Pyrroloquinoline Quinone (PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats.” Journal of clinical biochemistry and nutrition vol. 42,1 (2008): 29-34.
13. Huang, Yuanqing et al. “Effect and mechanism of pyrroloquinoline quinone on anti-osteoporosis in Bmi-1 knockout mice-Anti-oxidant effect of pyrroloquinoline quinone.” American journal of translational research vol. 9,10 4361-4374. 15 Oct. 2017.
14. Chowanadisai, Winyoo et al. “Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression.” The Journal of biological chemistry vol. 285,1 (2010): 142-52.
15. Bauerly, Kathryn et al. “Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats.” PloS one vol. 6,7 (2011): e21779.