What is Pantethine and How Can It Help Balance Cholesterol?

Cardiovascular issues are closely associated with cholesterol imbalance. Therefore, many people believe cholesterol is something to be avoided at all costs for fear of suffering from a heart attack or stroke. Even though high cholesterol is related to cardiovascular issues, completely eliminating cholesterol is not the answer.

Cholesterol is actually a necessary part of healthy bodily function and is required for the production of hormones, aids in digestion and, in appropriate amounts even, supports heart health.

Understanding the function of cholesterol and methods of regulating it is an important part of protecting heart health.

Is All Cholesterol Bad?

A major source of confusion regarding cholesterol is its multiple forms. There are two types of cholesterol; LDL (low-density lipoprotein) or “bad” cholesterol, and HDL (high-density lipoprotein) or “good” cholesterol.

LDL cholesterol has been identified as a major contributor to coronary heart disease and atherosclerosis. Alternatively, HDL cholesterol actually helps regulate arterial health by promoting the transport of both LDL and HDL cholesterol away from the arteries and preventing plaque build-up. Excess plaque in the arteries can lead to possible coronary failure, stroke and heart attack. As with most substances in the body, cholesterol in itself is not bad but an imbalance can cause serious issues.

What Can I Do to Balance My Cholesterol?

Typically, statins are the main method for treating high cholesterol. Current research has shown that these medications, in addition to lowering cholesterol, deplete enzymes such as CoQ10 and may contribute to the development of serious health issues such as diabetes, muscle and liver damage, and cognitive inhibition – learn more about the risk of statins here. Fortunately, there is a promising alternative.

Multiple studies have shown that pantethine, a derivative of vitamin B5, is a naturally synthesized substance that can lower cholesterol levels with few side effects.

Pantethine is the active form of pantothenic acid (more commonly known as vitamin B5). Even though pantethine is synthesized from B5, it is not considered a vitamin. Pantethine aids in breaking down fats and carbohydrates into usable forms of energy and supporting the production of red blood cell, sex hormones and stress hormones. It has also been studied for its positive impact on cholesterol and heart health.

Like the B vitamins, pantethine is not stored in the body because it is water soluble. Unused pantethine is flushed out of the body through urine. This means that acquiring enough of this critical cholesterol regulator requires an appropriate diet.

The Power of Pantethine

Pantethine has an impressive impact on cholesterol levels and may significantly reduce LDL cholesterol. A study published in Vascular Health and Risk Management in 2014 found that treatment with pantethine caused a significant decrease in LDL cholesterol levels. The course of the study lasted 16 weeks. During weeks one through eight, patients were administered 600 mg of pantethine daily. During the remaining eight weeks, participants received a daily 900 mg dose. Patients taking pantethine exhibited an 11% decrease in their baseline levels of LDL at weeks 4, 8, 12 and 16, whereas those taking the placebo experienced a 3% increase of LDL by week 16. Utilizing pantethine for cholesterol regulation could prove to be a powerful method of treatment.

How Does Pantethine Work?

The positive impact of pantethine is likely multifactorial. Additional research must be done to fully determine the specifics of how pantethine effects cholesterol level. However, researchers believe that pantethine positively impacts various cholesterol regulating substances. For example, it is understood that pantethine limits cellular levels of coenzyme carboxylase (CoA), which has a beneficial effect on how the body metabolizes cholesterol. Homocysteine is an amino acid associated with the development of atherosclerosis, or hardening of the arteries, as well as the production of CoA. Because pantethine influences CoA it is posited that it may also have a positive effect on homocysteine levels, thereby reducing the risk of atherosclerosis. However, further research must be done to confirm the specific influential functions of pantethine.

Getting the Pantethine the Body Needs

Diet is the primary source for necessary nutrients, vitamins and minerals. A poor diet can contribute significantly to increased levels of LDL cholesterol. Generally, foods that contain a high volume of saturated fats contribute to elevated cholesterol and greater risk of cardiovascular disease. Limiting intake of such foods and consuming more B5 and pantethine-rich foods can help alleviate high cholesterol.

The following foods provide a high amount of B5 and therefore increase the availability of pantethine in the body:

  • Avocado
  • Beef liver
  • Broccoli
  • Cauliflower
  • Chicken
  • Duck
  • Eggs
  • Grapefruit
  • Grass-fed beef
  • Kale
  • Lentils
  • Portobello Mushrooms
  • Salmon
  • Shellfish
  • Sun-dried tomatoes
  • Sunflower Seeds
  • Veal
  • Yogurt made with whole milk

For those unable to get enough pantethine through their diet, or individuals who want greater heart support, supplementation may be the solution.

HoltraCeuticals’ Pantethine is formulated specifically to regulate cholesterol levels and support cardiovascular health. Incorporating Pantethine into your supplemental regimen can help reduce LDL cholesterol, triglycerides and limit the risk of cardiovascular damage. Keep in mind that reckless use of any supplement may cause undesired results. When taken at higher doses, pantethine may cause diarrhea, nausea and flatulence. Consult a physician before supplementing heavily with pantethine.

Protecting the Heart with Pantethine

Because elevated LDL cholesterol is such a prominent component of heart disease, it is important to take appropriate precautions and measures to effectively regulate it. Improving pantethine prevalence in the body by consuming foods rich in pantethine and vitamin B5-rich foods or supplementing with products like Pantethine can help lower LDL cholesterol while improving cholesterol metabolization.

Knowing the multiple forms of cholesterol and utilizing pantethine to keep them appropriately balanced is an effective way to support your own cardiovascular wellness.

Watch as Holtorf Medical Group’s Health and Nutritional Coach explains cholesterol and the importance of a heart-healthy diet.


1. https://draxe.com/vitamin-b5/

2. https://articles.mercola.com/vitamins-supplements/pantothenic-acid.aspx

3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3942300/

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